The CDC 2006 treatment guidelines state that Azithromycin is more effective against M. genitalium than the other antibiotics usually used for urethritis treatment. Other research suggests that multi-day, as opposed to single dose, treatment with azithromycin may be most effective. A 10-day treatment regimen with Moxifloxacin may be a good option for those individuals with a mycoplasma infection when azithromycin is ineffective due to antibiotic resistance.
Sources:
Mycoplasma genitalium: Pathogen or Passenger? Medscape Infectious Diseases. 2008 (Accessed 3/16/08)

